Table 3.

C-statistics for Models with SUA, SBP, DBP, HbA1c and LDL-C as Continuous Variables

Model 1 (HbA1c, SBP, DBP and LDL-C) vs. model 2 (model 1 + SUA)
Models	AUC (95% CI)	ΔAUC	IDI (±SE)	Relative IDI* (%)
CAC progression (n=199)
Model 1 (model 1: HbA1c, SBP, DBP and LDL-C)	0.67 (0.62–0.73)
Model 1 + SUA (model 1: HbA1c, SBP, DBP and LDL-C)	0.72 (0.68–0.77)
SUA + Model 1 vs Model 1 (model 1: HbA1c, SBP, DBP and LDL-C)		0.05 (p=0.005)	0.05±0.01 (p<0.0001)	12.2% (p<0.0001)
Incident albuminuria (n=27)
Model 1 (model 1: HbA1c, SBP, DBP and LDL-C)	0.67 (0.55–0.80)
Model 1 + SUA (model 1: HbA1c, SBP, DBP and LDL-C)	0.73 (0.61–0.84)
SUA + Model 1 vs Model 1 (model 1: HbA1c, SBP, DBP and LDL-C)		0.06 (p=0.20)	0.04±0.02 (p=0.02)	35.1% (p=0.02)
Rapid GFR decline (n=50)
Model 1 (model 1: HbA1c, SBP, DBP and LDL-C)	0.69 (0.60–0.77)
Model 1 + SUA (model 1: HbA1c, SBP, DBP and LDL-C)	0.70 (0.62–0.79)
SUA + Model 1 vs Model 1 (model 1: HbA1c, SBP, DBP and LDL-C)		0.02 (p=0.27)	0.01±0.01 (p=0.11)	6.5% (p=0.11)
Incident diabetic retinopathy (n=71)
Model 1 (model 1: HbA1c, SBP, DBP and LDL-C)	0.65 (0.58–0.72)
Model 1 + SUA (model 1: HbA1c, SBP, DBP and LDL-C)	0.68 (0.61–0.75)
SUA + Model 1 vs Model 1 (model 1: HbA1c, SBP, DBP and LDL-C)		0.03 (p=0.19)	0.02±0.01 (p=0.01)	14% (p=0.01)
Incident peripheral diabetic retinopathy (n=35)
Model 1 (model 1: HbA1c, SBP, DBP and LDL-C)	0.73 (0.64–0.82)
Model 1 + SUA (model 1: HbA1c, SBP, DBP and LDL-C)	0.77 (0.69–0.86)
SUA + Model 1 vs Model 1 (model 1: HbA1c, SBP, DBP and LDL-C)		0.04 (p=0.31)	0.05±0.02 (p=0.01)	38% (p=0.01)

^*Relative IDI – calculated as the ratio of IDI over the discrimination slope of the model without the new variable (i.e. SUA).