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. Author manuscript; available in PMC: 2015 Apr 16.
Published in final edited form as: Pediatr Res. 2012 Oct 24;73(1):38–45. doi: 10.1038/pr.2012.142

Figure 1.

Figure 1

Caffeine treatment significantly increased the number of episodes of asphyxia withstood by neonatal Pet-1−/− mice. (a) Survival curves for vehicle-treated wild-type (n = 17; solid circles) and Pet-1−/− littermates (open symbols) given an i.p. injection of vehicle (n = 10; circles) or caffeine at doses of 1 mg/kg (n = 9; triangles), 5 mg/kg (n = 12; diamonds), or 10 mg/kg (n = 8; squares). Survival curves for wild-type animals treated with caffeine are not significantly different from those treated with vehicle; for the purposes of clarity of the figure, these data are not shown. (b) Individual animals (small circles) and median number of episodes survived (large symbols ± 95% confidence interval) for wild-type animals (solid symbols) and Pet-1−/− littermates (open circles, doses represented by same symbols as are used in (a). *Significant interaction between caffeine dose and genotype, P < 0.001. Note that asymmetric data distribution, given our paradigm, uses a maximum of 10 hypoxic episodes.