. Author manuscript; available in PMC: 2015 Apr 16.

Published in final edited form as: Pediatr Res. 2012 Oct 24;73(1):38–45. doi: 10.1038/pr.2012.142

Table 2.

Effect of drug or saline injection on baseline cardio-respiratory parameters

Genotype	Treatment	HR_pre-	HR_post-	V̇_{E_pre-}	V̇_{E_post-}	V̇_O₂pre-	V̇_O₂post-	V̇_E/V̇_O₂pre-	V̇_E/V̇_O₂post-
WT (n = 17)	Veh	539 ± 36	553 ± 18	1,005 ± 179	996 ± 158	51.3 ± 9.0	50.4 ± 7.5	19.8 ± 2.0	19.2 ± 2.0
Pet-1^−/− (n = 10)		496 ± 27	518 ± 21	1,100 ± 152	1,057 ± 71	41.6 ± 6.0	41.2 ± 6.2	26.8 ± 2.8	26.6 ± 3.2
WT (n = 9)	1 mg/kg	487 ± 45	519 ± 34	833 ± 106	922 ± 112	44.3 ± 5.2	50.3 ± 7.1	18.9 ± 1.5	22.0 ± 1.0
Pet-1^−/− (n = 9)		484 ± 39	480 ± 30	1,026 ± 135	993 ±133	45.4 ± 7.5	44.1 ± 8.3	23.2 ± 3.4	23.1 ± 2.4
WT (n = 13)	5 mg/kg	583 ± 32	588 ± 37	1,264 ± 143	1,174 ± 108	54.9 ± 7.4	52.2 ± 5.9	23.7 ± 2.4	23.4 ± 3.5
Pet-1^−/− (n = 12)		548 ± 49	554 ± 43	1,235 ± 115	1,239 ± 130	44.4 ± 6.5	47.0 ± 5.9	28.7± 3.0	26.9 ± 24
WT (n = 16)	10mg/kg	527 ± 32	582^* ± 23	958 ± 79	1,050 ± 86	42.7 ± 3.1	44.9 ± 4.1	22.6 ± 1.7	24.1 ± 2.7
Pet-1^−/− (n = 8)		444 ± 28	487^* ± 54	953 ± 72	1,043 ± 125	37.3 ± 4.6	47.0 ± 12.0	26.1 ± 3.1	23.5 ± 3.7

Values for heart rate (HR, beats/min), ventilation (V̇_E, ml/min/kg), metabolic rate (V̇_O₂, ml/min/kg), and the ventilatory equivalent (V̇_E/V̇_O₂) during room air conditions in wild-type (WT) and Pet-1^−/− pups before (pre-) and following (post-) treatment with either vehicle (Veh) or 1, 5, and 10 mg/kg caffeine.

Significant effect of caffeine or vehicle, P < 0.05. Shown are mean data ± 95% confidence interval.