Table 4. Incidence and hazard ratio for the osteonecrosis cohort compared to the comparison cohort.
Annual Frequency of Dental Extraction | Comparison | Osteoporosis | ||
---|---|---|---|---|
Mild | Serious | P for trend | ||
Low* | 1.00 | 1.69 (0.90–3.16) | 2.19 (0.75–6.38) | 0.08 |
Median † | 3.11 (1.81–5.37)*** | 4.47 (2.41–8.31)*** | 7.12 (2.87–17.6)*** | 0.07 |
High ‡ | 15.9 (9.69–26.0)*** | 39.2 (23.9–64.4)*** | 46.6 (24.7–87.9)*** | <0.0001 |
P for trend | <0.0001 | <0.0001 | <0.0001 |
Adjusted model; model adjusted for age, gender, hypertension, diabetes and cancer.
*Low: < once annually;
†Median: once or twice annually;
‡High: > twice annually.
***P<0.001.