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. Author manuscript; available in PMC: 2015 Apr 16.
Published in final edited form as: Biochem Soc Trans. 2013 Aug;41(4):981–986. doi: 10.1042/BST20130120

Figure 3. The A70F mutation short-circuits the activation mechanism for B-Raf.

Figure 3

The general steps of the activation process are summarized on the top. Mutating Ala481 to phenylalanine creates a dead kinase that short-circuits part of the activation process, but can still dimerize and lead to downstream activation of ERK.