Table 4. Characteristics of male and female offspring of fathers and mothers that received standard chow (SC) and/or high-fat (HF) diet.
Male | SC-Mo/SC-Fa | SC-Mo/HF-Fa | HF-Mo/SC-Fa | HF-Mo/HF-Fa |
---|---|---|---|---|
Initial body mass (g) | 1.20±0.04a | 1.23±0.08a | 1.26±0.05a | 1.50±0.05 b |
Body mass at weaning (g) | 9.80±0.85a | 9.90±0.58a | 11.50±0.67b | 12.68±0.77c |
Final body mass (g) | 25.03±0.35a | 25.53±0.97a | 28.60±1.10b | 31.72±0.88c |
Food intake (g/day/mouse) | 2.20±0.32a | 2.36±0.38a | 3.49±0.43b | 4.40±0.34c |
Energy intake (kJ/day/mouse) | 36.32±5.30a | 38.97±6.36a | 57.62±4.82b | 72.65±5.53c |
Fasting glucose (mmol/L) | 4.55±0.52a | 6.69±0.35b | 8.12±0.48b | 10.21±1.07c |
Adiposity Index (%) | 2.42±0.27a | 2.40±0.27a | 3.86±0.53b | 5.39±0.45c |
Total cholesterol (mg/dL) | 67.67±3.14a | 70.45±13.10a | 90.20±2.65b | 112.90±6.36c |
Triacylglycerol (mg/dL) | 54.75±1.08a | 57.00±7.50a | 65.77±4.39b | 79.90±6.05c |
Insulin (pg/mL) | 88.60±3.75a | 140.20±9.29b | 243.50±33.27c | 377.80±7.62d |
Adiponectin (106 pg/mL) | 7.40±0.43a | 6.04±0.50b | 4.65±0.88c | 3.22±0.29d |
Hepatic mass (g/cm) | 0.34±0.04a | 0.53±0.04b | 0.50±0.06b | 0.70±0.05c |
Liver TG (mg/dl/mg) | 2.79±0.46a | 4.71±0.89b | 4.90±0.77b | 6.60±0.34c |
Female | ||||
Initial body mass (g) | 1.13±0.03e | 1.14±0.04e | 1.20±0.10e | 1.36±0.05f, * |
Body mass at weaning (g) | 8.96±0.85e,* | 8.99±0.58e,* | 10.01±0.67f,* | 11.90±0.78g,* |
Final body mass (g) | 19.13±0.39e,* | 19.18±0.63e,* | 21.37±0.83f,* | 23.47±0.74g,* |
Food intake (g/day/mouse) | 1.98±0.50e | 1.98±0.42e | 2.76±0.38f,* | 3.52±0.77g,* |
Energy intake (kJ/day/mouse) | 32.69±8.20e | 32.69±6.94e | 45.57±6.26f,* | 58.12±12.76g,* |
Fasting glucose (mmol/L) | 3.97±0.35e | 5.72±0.26f | 6.04±1.04f,* | 7.78±0.81g,* |
Adiposity Index (%) | 3.14±0.06e | 3.00±0.17e | 4.85±0.20f,* | 6.93±0.30g,* |
Total cholesterol (mg/dL) | 58.17±2.48e | 60.13±6.46e | 76.83±4.75f, * | 95.62±8.43g,* |
Triacylglycerol (mg/dL) | 53.60±2.67e | 55.46±1.43e | 60.65±1.90e,* | 71.13±2.55f,* |
Insulin (pg/mL) | 85.98±6.27e | 136.60±36.49f | 198.40±21.82g,* | 279.80±10.90h,* |
Adiponectin (106 pg/mL) | 8.30±0.51e | 7.02±0.48f | 5.66±0.90g,* | 4.29±0.43h,* |
Hepatic mass (g/cm) | 0.32±0.04e | 0.48±0.05f | 0.42±0.07f | 0.61±0.07g |
Liver TG (mg/dl/mg) | 2.64±0.13e | 4.33±0.76f | 4.46±0.80f | 6.25±1.14g |
All offspring groups received postnatal SC diet (n = 5). Data are expressed as the mean and SD (n = 5 mice per group, one way ANOVA and the post hoc test of Holm-Sidak). Same letters represent equal groups, with no statistical difference while different letters represent different groups from each other, with statistical difference (P<0.05)
* different from the corresponding counterpart (P<0.05).
Abbreviations: offspring of SC mother and SC father (SC-Mo/SC-Fa); offspring of SC mother and HF father (SC-Mo/HF-Fa); offspring of HF mother and SC father (HF-Mo/SC-Fa); offspring of HF mother and HF father (HF-Mo/HF-Fa); triacylglycerol (TG).