Table 1. Group demographics and clinical summary.

	NC	MCI	CONV	AD	p-value(a)
N	97	65	54	39
% Male	48	56	56	55	0.12
APOE ε4 carriers (%)	33	40	48	51	< 0.001
Age (years)	75.4±5	75.0±5	74.7±5	74.5±6	0.21
ADAS-Cog11(b)	5.6±2	9.5±4	12.9±5	18.1±6	< 0.001
% Annual Change (c) ADAS-Cog11	-8±80	7±53	26±47	42±34	< 0.001

(a) P-values indicate effects across groups using analysis of variance (ANOVA) or Fisher exact test (for categorical variables, e.g. male and APOE) (b) Alzheimer’s Disease Assessment Scale-cognitive subscale with 11 items (Mohs et al. 1997); total score range from 0–70; larger scores indicating greater impairment. (c) % Annual change is expressed relative to baseline in percent.