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. 2015 Apr 16;10(4):e0123463. doi: 10.1371/journal.pone.0123463

Fig 4. Insertion within WD repeat 2.

Fig 4

(a) The insertion (red) forms an important protrusion on the bottom of the domain. (b) Position of the insertion (red) in the context of the second blade only. Residues corresponding to WD repeat 2 are represented in light blue and the strand D of WD repeat 3 is shown in dark blue. (c) Comparison of blades 1 and 2 of WDR5 from H. sapiens (PDB:4CY2; pink) and Erb1 (blue). Side chains of conserved tryptophan corresponding to the strand C (in canonical WD repeats) are shown for both proteins. Black arrows indicate the position of 2D-2A loops. The letters in (b) and (c) indicate the position of each strand.