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. Author manuscript; available in PMC: 2016 Apr 13.
Published in final edited form as: Cancer Cell. 2015 Apr 6;27(4):462–472. doi: 10.1016/j.ccell.2015.02.015

Figure 2. Macrophage polarization as a dynamic system.

Figure 2

The integration of multiple signals emanating from the tumor microenvironment (outer circle) dictates the functional role of macrophages (inner circle). Integrins and toll-like receptors (TLRs) will be engaged by multiple ligands.