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Structure of the PRMT3–SGC707 complex. SGC707 (magenta) binds an allosteric site at the interface of the two PRMT3 subunits that is distant from the site of methyl transfer (red star). The allosteric site comprises a PRMT3-specific pocket in one subunit (yellow/orange) and a portion of the “activation α-helix” (light blue) of the other subunit.
