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. 2015 Apr 8;17(4):489–499. doi: 10.1016/j.chom.2015.03.004

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© 2015 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

SAM Domain-SIV_mnd-2 Vpx Interactions

(A) The SAMHD1_mnd SAM domain-SIV_mnd-2 Vpx interface. The SAMHD1_mnd SAM domain (magenta) and SIV_mnd-2 Vpx (blue) are shown in cartoon representation. Residues making interactions are shown in stick representation with hydrogen bonding and salt bridges displayed as dashed lines.

(B and C) Quantification of reporter expression in cells stably expressing SAMHD1_mnd (1–114) degron reporter constructs with (B) SAM domain point mutations and (C) mandrill to human SAMHD1 amino acid substitutions. Cells were transduced with increasing titers of particles expressing SIV_mnd-2 Vpx, and the level of transduction (YFP) and degron reporter (EGFP) expression was measured by flow cytometry.