Conformation of the E2412–423 epitope bound to HC33.1 and other broadly neutralizing antibodies.
A, structure of E2412–423 in complex with HC33.1. Only backbone atoms of the peptide are shown: carbon atoms in yellow, nitrogen atoms in blue, and oxygen atoms in red. Hydrogen bond stabilizing the backbone conformation is drawn as dotted lines. The N and C termini are labeled (N-ter and C-ter, respectively). B, structure of E2412–423 in complex with HCV1. C, structure of E2412–423 in complex with 3/11. D, superposition of E2412–423 epitopes from complexes with HC33.1 (yellow), HCV1 (green), and AP33 (magenta) through residues 416–419 of the peptide β-turn.