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. 2015 Mar 3;290(16):10117–10125. doi: 10.1074/jbc.M115.643528

FIGURE 3.

FIGURE 3.

Conformation of the E2412–423 epitope bound to HC33.1 and other broadly neutralizing antibodies. A, structure of E2412–423 in complex with HC33.1. Only backbone atoms of the peptide are shown: carbon atoms in yellow, nitrogen atoms in blue, and oxygen atoms in red. Hydrogen bond stabilizing the backbone conformation is drawn as dotted lines. The N and C termini are labeled (N-ter and C-ter, respectively). B, structure of E2412–423 in complex with HCV1. C, structure of E2412–423 in complex with 3/11. D, superposition of E2412–423 epitopes from complexes with HC33.1 (yellow), HCV1 (green), and AP33 (magenta) through residues 416–419 of the peptide β-turn.