FIGURE 4.
Temperature factors of the main chain of W165Y/E166Y/P167G/L201P (salmon) and TEM-1 (PDB code 1XPB) (dark cyan). The corresponding β-lactamase structures are shown above the temperature factor curves. On the left in dark cyan is TEM-1, and on the right is W165Y/E166Y/P167G/L201P in salmon. The Ω-loop is outlined in the black boxes. The peak in the temperature factor curve corresponds to an increase in the B-factors of residues 167–172 in W165Y/E166Y/P167G/L201P. The numbering follows the conventional numbering for class A β-lactamases.