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. 2015 Mar 9;290(16):10447–10459. doi: 10.1074/jbc.M114.609230

FIGURE 6.

FIGURE 6.

Membrane and INFS FGFR1 signaling regulates FGF-23 in a cooperative fashion. A and B, human and mouse FGF-23 promoter DNA sequence containing wild-type NFAT and CREB sites, and NFAT site mutation, CREB mutation, or both NFAT and CREB site mutations. Effect of LMW-FGF-2 (50 ng/ml), HMW-FGF-2 and FSK, or HMW-Fgf-2 and FSK plus LMW-FGF-2 on the promoter activity of the wild-type FGF-23 reporter (C and E), CREB mutant (D and F), NFAT mutant (G and I), or CREB/NFAT mutant (H and J), respectively. Data are expressed as the mean ± S.D. from three independent experiments. Values sharing the same superscript in different groups are not significantly different. *, p < 0.05; **, p < 0.01 versus control vector group, respectively.