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EtOH inhibits OPN-mediated MZF1-luciferase construct activation. A, schematic depiction of MZF1 promoter-luciferase reporter constructs. B, luciferase activity of MZF1 promoter constructs in MSC (*, p < 0.0001). C, schematic representation of the wild type and mutated MZF1 binding site within the MZF1 promoter sequence. D, luciferase activity of the wild type and mutant MZF1 promoter constructs in MSC (*, p < 0.0001). Data are presented as mean ± S.E. of at least three experiments.
