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. 2012 Feb;5(1):17–27. doi: 10.1093/ckj/sfs001

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© The Author 2012. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com

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Fig. 3. — Endothelin mediates podocyte injury in vitro. (a, b) Actin-phalloidin immunofluorescence (left) and phase-contrast images of actin cytoskeleton fibres and cell morphology (right panels) in a normal podocyte. (c, d) Puromycin aminonucleoside (PAN)-induced foot process effacement, cytoskeleton disruption (disappearance of actin fibres) and cell body shrinkage. (e, f) Prevention of PAN-induced injury by the ET_A antagonist BQ-123. (g, h) Prevention of PAN-induced injury by the ET_A antagonist darusentan/ LU135252. (i, j) The ET_B receptor antagonist BQ-788 had no effect on PAN-induced injury. Figure reproduced from reference [39] and reproduced with permission of the publisher.