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. 2015 Mar 19;4(4):645–657. doi: 10.1016/j.stemcr.2015.02.009

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© 2015 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).

PMC Copyright notice

miR-302/367 Cluster Predominantly Regulates Apoptosis in hESCs

(A) Percentage of apoptotic cells in hESCs expressing control-KRAB, TALE1-KRAB, BCL-xL, or both TALE1-KRAB and BCL-xL. Cells were stained with Annexin V-APC and analyzed by flow cytometry. Data are represented as mean ± SD of three independent experiments (^∗p < 0.05, ^∗∗p < 0.01). See also Figure S4.

(B) Effect of apoptosis on cell growth of hESCs with knockdown of miR-302/367 cluster. hESCs expressing either TALE1-KRAB (left) or both TALE1-KRAB and BCL-xL (right) were cultured, passaged for several times, and then analyzed for GFP⁺ cells. The percentage of GFP⁺ cells was calculated for hESCs expressing TALE1-KRAB or both TALE1-KRAB and BCL-xL before and after passaging (lower). Data are represented as mean ± SD of three independent experiments (^∗∗p < 0.01; N.S, no significance).