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A Model for Action of miR-302/367 Cluster in Regulation of Cell Cycle and Apoptosis in hESCs
miR-302/367 cluster is inducible by sodium butyrate in hESCs, and it is required to sustain expression of key cell cycle regulators such as BMI-1, CCND1, CCND2, and CDK6. At the same time, a minimum level of miR-302/367 cluster is needed to inhibit spontaneous apoptosis in hESCs by modulates expression of BCL-xL and BH3-only proapoptotic factor BNIP3L/Nix.
