Table 1.

Demographics, indications, and types of pain in 41 patients prescribed methadone

	n (percent)
Sex
Male	24 (58.5)
Female	17 (41.5)
Age, y
Range, 0.6–23
≤10	7 (17)
11–17	16 (39)
≥18	18 (44)
Primary diagnosis
Leukemia/lymphoma	13 (31.2)
Leukemia	10
Lymphoma	3
Solid tumor	23 (56.1)
Osteosarcoma	7
Rhabdomyosarcoma	5
Ewing sarcoma	2
Brain tumor	2
Other*	7
Hematologic or congenital disorders	5 (9.8)
Thalassemia	1
Sickle cell disease	1
Fanconi anemia	1
Myelodysplastic syndrome	1
Osteopetrosis	1
Primary cause of pain
Bone marrow transplant	13 (31.7)
Amputation	6 (14.6)
Chemotherapy	5 (12.2)
Tumor	5 (12.2)
Limb-sparing surgery	4 (9.8)
Other	8 (19.5)
Methadone clinical use†	n = 51†
Control of neuropathic pain	20 (39.2)
Control of nociceptive pain	17 (33.3)
Opioid weaning/prevention of withdrawal	11 (21.6)
End-of-life pain management	3 (5.9)

^*Other: neuroblastoma, undifferentiated sarcoma, Wilms tumor, adrenocorticoid carcinoma, alveolar soft part sarcoma, angiosarcoma, and hepatoblastoma.

^†Fifty-one patients had two concurrent indications for methadone use.