Table 3.

Pain score change, duration of methadone treatment, and concomitant therapies in 14 young patients

	Primary diagnosis	Type of pain	Clinical use for methadone therapy	Maximum pain score* at start of therapy	Maximum pain score* at end of therapy	Duration of methadone therapy, wk	Concomitant therapies†
1	Non-Hodgkin lymphoma	Mixed‡	Nociceptive pain, neuropathic pain	10	0	8	CT, fentanyl, gabapentin
2	Osteosarcoma	Neuropathic	Neuropathic pain	9	0	12	CT, morphine, gabapentin
3	Osteosarcoma	Neuropathic	Neuropathic pain	8	0	20	CT, morphine, gabapentin, amitriptyline
4	Neuroblastoma	Nociceptive	Nociceptive pain	8	0	3	CT, morphine, fentanyl
5	AML	Undocumented	Prevention of opioid withdrawal	8	0	4	CT, morphine
6	Ewing sarcoma	Mixed‡	Neuropathic pain	7	0	8	CT, morphine, gabapentin, amitriptyline
7	Osteosarcoma	Mixed‡	Nociceptive pain, neuropathic pain	6	0	2	CT, morphine, fentanyl, amitriptyline
8	ALL	Neuropathic	End-of-life pain	9	8	4	Hydromorphone, fentanyl
9	Osteosarcoma	Mixed‡	Nociceptive pain, neuropathic pain	8	7	1	CT, morphine, hydromorphone, gabapentin
10	Rhabdomyosarcoma	Neuropathic	Prevention of opioid withdrawal, neuropathic pain	7	7	12	CT, fentanyl, gabapentin
11	Sickle cell disease	Mixed‡	Nociceptive pain, neuropathic pain	10	10	12	CT, fentanyl, gabapentin
12	Primitive neuroectodermal tumor	Mixed‡	Neuropathic pain	4	4	4	CT, morphine, oxycodone, gabapentin
13	Myelodysplastic syndrome	Neuropathic	Neuropathic pain	7	8	12	Gabapentin
14	ALL	Undocumented	Prevention of opioid withdrawal	1	6	12	CT, fentanyl

Abbreviations: AML, acute myeloid leukemia; ALL, acute lymphoblastic leukemia; CT, chemotherapy.

^*Pain scale: 0–10.

^†Concomitant pain medications and cancer-directed treatments.

^‡Patients had both neuropathic and nociceptive pain.