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. Author manuscript; available in PMC: 2016 Mar 15.
Published in final edited form as: Cancer Res. 2015 Jan 16;75(6):1035–1045. doi: 10.1158/0008-5472.CAN-13-1625

Figure 2. Development of lung adenocarcinomas in mice lacking ERBB3.

Figure 2

(A) Kaplan-Meier survival curves comparing CCSP-rtTA+;TetO-EGFRL858R+ mice with (Erbb3 +/+, Erbb3fl/fl; Cre−, Erbb3 fl/+; Cre−), without (Erbb3 fl/fl; Cre+) or heterozygous for (Erbb3 fl/+; Cre+) Erbb3. L56, transgenic line 56. (B) Hematoxylin and Eosin staining of EGFRL858R-induced tumors that developed in the presence and absence of ERBB3. Representative images of mouse lungs from mice on doxycycline for approximately two months are shown. Bar, 100μm. (C) Hematoxylin and Eosin staining of EGFRΔ747-752-induced tumors that developed in the presence and absence of ERBB3. Representative images of mouse lungs from mice on doxycycline for approximately four months are shown. Bar, 100μm.