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. 2015 Apr 17;9:117. doi: 10.3389/fncel.2015.00117

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Copyright © 2015 Hahn, Wang and Margeta.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Glia-induced NMDAR current enhancement is mediated by PKC. (A) Representative current traces evoked by 100 μM NMDA in the presence of 1 μM glycine recorded after 40 min pretreatment with either vehicle (0.1% DMSO) or GFX (5 μM). Horizontal scale bar, 10 s; vertical scale bar, 250 pA. (B) GFX pretreatment blocked the glia-induced potentiation of NMDA-evoked currents in mixed cultures but had no effect in neuronal cultures (**p < 0.01, ***p < 0.001, two-way ANOVA with Bonferroni post-test). (C) Representative current traces evoked by 100 μM NMDA in the presence of 1 μM glycine recorded after 10 min pretreatment with either vehicle (0.1% DMSO) or PMA (100 nM). Horizontal scale bar, 10 s; vertical scale bar, 250 pA. (D) PMA pretreatment significantly increased NMDAR current density in neuronal cultures but had no effect in mixed cultures (***p < 0.001, two-way ANOVA with Bonferroni post-test).