Table 1. Summary of TPC-1 growth on day 4 using combination of CI-1040 and Src inhibitors.
Treatment | Reduction (%) | p value vs mock* | p value vs CI-1040 alone* |
---|---|---|---|
1 μM CI-1040 | 59.7 | < 0.001 | n/a |
0.1 μM PP2 | 36.2 | < 0.001 | n/a |
1 μM CI-1040 + 0.1 μM PP2 | 73.1 | < 0.001 | <0.007 |
1 μM PP2 | 71.4 | < 0.001 | n/a |
1 μM CI-1040 + 1 μM PP2 | 87 1 | < 0.001 | <0.001 |
0.1 μM SU6656 | 29.9 | < 0.001 | n/a |
1 μM CI-1040 + 0.1 μM SU6656 | 68.7 | < 0.001 | 0.01 |
1 μM SU6656 | 61.4 | < 0.001 | n/a |
1 μM CI-1040 + 1 μM su6656 | 77.5 | < 0.001 | <0.001 |
0.01 μM Dasatinib | 36.7 | < 0.001 | n/a |
1 μM CI-1040 + 0.01 μM Dasatinib | 74.0 | < 0.001 | 0.001 |
0.1 μM Dasatinib | 69.2 | < 0.001 | n/a |
1 μM CI-1040 + 0.1 μM Dasatinib | 84.8 | < 0.001 | <0.001 |
p value was determined by Student t-test