Table 3.
Hormone levels, basal and after administration of 1 μg ACTH and 0.25 mg dexamethasone (dex) – healthy subjects vs T2D, subdivided by gender.
| T2D men (n=11) | T2D women (n=10) | P T2D men vs women | Healthy men (n=20) | Healthy women (n=18) | P healthy men vs women | P T2D vs healthy men | P T2D vs healthy women | |
|---|---|---|---|---|---|---|---|---|
| S-IGF1, basal (s.d.) | 0.4±0.5 | 0.2±0.3 | NS | 0.2±0.2 | 0.3±0.2 | NS | NS | NS |
| S-IGFBP1, basal (μg/l) | 37±4 | 34±5 | NS | 32±4 | 38±5 | NS | NS | NS |
| S-cortisol, basal before ACTH (nmol/l) | 451±43 | 391±26 | NS | 368±22 | 403±22 | NS | NS | NS |
| S-cortisol, peak after ACTH (nmol/l) | 691±42 | 696±47 | NS | 582±21 | 675±26 | 0.023 | 0.024 | NS |
| Δ cortisol after ACTH (nmol/l) | 240±31 | 305±42 | NS | 214±23 | 267±17 | NS | NS | NS |
| S-cortisol, basal before dex (nmol/l) | 473±40 | 423±43 | NS | 409±22 | 380±22 | NS | NS | NS |
| S-cortisol, after dex (nmol/l) | 321±42 | 244±24 | NS | 280±21 | 240±22 | NS | NS | NS |
| Δ cortisol after dex (%) | −32.0±7.3 | −40.4±5.8 | NS | −32.2±2.9 | −39.7±5.1 | NS | NS | NS |
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