2.

Schematic depiction of Tie2 signallingsignaling regulation. Ang-1 activation of Tie2 subsequently leads to Tie2 internalization and degradation. Tie2 activation can also be inhibited by Ang-2 competitive binding. Stimulator such as PMA (phorbol 12-myristate 13-acetate) and basic FGF (basic fibroblast growth factor) can induce Tie2R shedding, leaving the extracellular domain (sTie2RFc) in the area. sTie2Fc can compete with Tie2 for Ang-1 binding. Vascular endothelial protein phosphatase associates with Tie2 and can also regulate the activity of the tyrosine kinase domain.