1.

Effect of mediators on the expression of Tie1 and Tie2, and production and secretion of Ang-1 and Ang-2

Stimulus	Tie1 expression	Tie2 expression	Ang-1 production	Ang-2 production
TNF-α		Increase [54, 57] or decrease [56, 59] in cell type dependent manner	Increase in cell type dependent manner [54]
TGF-β		Increase in rheumatoid synovial fibroblast [54]	Increase in normal fibroblast [54]
IL-1β		Decrease [56]
VEGF		Transient acute increase in cell type dependent manner [42]	Increase [62] and transient acute increase in a cell type dependent manner [42],	Increase in cell type dependent manner [42, 60-62]
IL-11	Increase [16]
Hypoxia	Increase [41]	Increase [41] and transient acute increase in cell type dependent manner [42],	Transient acute increase in a cell type dependent manner [42]	Increase [55, 60, 61] and increase in a cell type dependent manner [42]

^*The numbers in the brackets represent the corresponding citation of the findings.