4.

Additional examples of interactions between ion channel or receptor proteins and membrane lipids

Membrane protein	Observed lipid effect	References
Kv 2.1	Cholesterol depletion favours inactivation	[329]
Kv 1.3	Ceramide inhibits channel activity	[330]
Kv 1.5	Targeted to caveola lipid rafts	[329]
Ca2+ activated K+ channels	Requires anionic phospholipids for channel activation Modulated by lipid bilayer thickness	[140]
KATP channel	Activation proportional to number of negative charges on the lipid head group	[331]
TREK	Activation by lysophospholipids as a function of acyl chain length and polar head group size	[332]
ENaC	Anionic phospholipids may mediate their regulation	[143]
TRP Ca2+ channels	The existence of a lipid domain modulated the activity of the channel	[333]
NMDA	Correlation between membrane tension (induced by either mechanical or chemical stimuli) and internal Mg2+ block	[334]
α7 nNAcChR	Target to lipid rafts in the somatic spines of ciliary neurons	[335]