1.

Proteins with which the CaR interacts. Table 1 lists the CaR interacting proteins that have been described so far alphabetically in the first column. The second column lists the function of the interacting protein. The third column lists the experimental basis for the interaction of a protein with the CaR, Y2H for yeast two hybrid, Co-IP for co-immunoprecipitation, GST for GST pull-down assays and functional if expression or mutagenesis studies indicate that the interaction is functionally significant. The fourth column (CaR domain) identifies the region of the CaR that interacts with the protein shown at left. The fifth column states whether co-localization studies of the CaR were performed with the interacting protein. Native means that studies were performed in native tissue, and Het means that studies were performed in heterologous expression systems. The sixth column provides essential references for the observations

Interacting Protein	Function	Interaction	CaR Domain	Co-localization	Reference
AMSH	Trafficking/de Ub enzyme	Y2H, GST	C-term		(80)
β-Arrestin	Trafficking/signalling	Functional	?		(77)
Caveolin-1	Structural/scaffolding	Co-IP	?	Native, Het	(81; 84)
E3 Ub ligase	Trafficking	Y2H, IP, Functional	C-term	Het	(79)
Filamin	Scaffolding/structural/-trafficking	Y2H, Co-IP, GST, functional	C-term	Native, Het	(15; 40; 41)
GRK-2	Signalling	Functional	?		(77)
GRK-4	Signalling	Functional	?		(77)
Kir4.1	K channel	Y2H, Co-IP, functional	C-term	Native, Het	(54)
Kir4.2	K channel	Y2H, Co-IP, functional	C-term	Het	(54)
PI-4-kinase	Signalling	Co-IP	?		(71)
PKC	Signalling	Functional	C-term		(77)
RAMP1	Structural/trafficking	Co-IP, Functional	?ECD and TM	Het	(37)
RAMP3	Structural/trafficking	Co-IP, Functional	?ECD and TM	Het	(37)
RGS proteins	Signalling	Functional	?		(16; 71)
Rho	Signalling	Co-IP	?		(71)