2.

Class II Biomarkers of liver fibrogenesis

Index	Parameters	Chronic liver disease	Sensitivity (%)	Specificity (%)	References
PGAA-Index	Prothrombin time, γGT, apolipoprotein A1, α2-macroglobulin	Alcohol	79	89	[112]
Bonacini-index	ALT/AST-ratio, INR, platelet count	HCV	46	98	[113]
Sheth-index	AST/ALT (De Ritis)	HCV	53	100	[114]
Park-index		HCV	47	96	[115]
PGA-Index	Prothrombin time, γGT,	Mixed	91	81	[116]
	apolipoprotein A1		[117]
Fortunato-score	Fibronectin, prothrombin time, PCHE, ALT, Mn-SOD, β-NAG	HCV		94	[118]
Fibrotest	Haptoglobin, α2-macroglobulin,	HCV	75	85	[58–60]
(Fibro-score)	apolipoprotein A1. γGT, bilirubin	HBV
Pohl-score	AST/ALT-ratio, platelet count	HCV	41	99	[119]
Actitest	Fibrotest + ALT	HCV		[59]
Forns-index	Age, platelet count, γGT, cholesterol	HCV	94	51	[120]
Wai-index (APRI)	AST, platelet count	HCV	89	75	[61]
Rosenberg-score (ELF-score)	PIIINP, hyaluronan, TIMP-1	Mixed	90	41	[62]
Patel-index (FibroSpect)	hyaluronan, TIMP-1, α2-macroglobulin	HCV	77	73	[121]
Sud-index (fibrosis probability-index, FPI)	age, AST, cholesterol, insulin resistance (HOMA), past alcohol intake	HCV	96	44	[122]
Leroy-Score	PIIINP, MMP-1	HCV	60	92	[123]
Fibrometer test	Platelet count, prothrombin index, AST, α2-macro-globulin, hyaluronan, urea, age	Mixed	81	84	[124]
Hepascore	Bilirubin, γGT, hyaluronan, α2-macroglobulin, age, gender	HCV	63	89	[63]
Testa-index	Platelet count / spleen diameter-ratio	HCV	78	79	[125]
FIB-4	Platelet count, AST, ALT, age	HCV/HIV	70	74	[126]
FibroIndex	Platelet count, AST, γ-globulin	HCV	38	97	[127]

Abbreviations: GGT, γ-glutamyltransferase; PIIINP, N-terminal pro-peptide of type III pro-collagen; TIMP, tissue inhibitors of metalloproteinases; MMP, matrix metalloproteinases; β-NAG, N-acetyl-β-glucosaminidase; AST, aspartate aminotransferase; ALT, alanine aminotransferase; INR, international normalized ratio.