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7.

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Localization of FAK and vWF and co-localization of DDR-2 and c-Kit in Cav-1+/+ and Cav-1−/− mouse LVM. In Cav-1+/+ mouse FAK (red, open arrows) appears at FB and vWF (green, closed arrows) does at CEC, but these are not co-localized (A–C). Interestingly some DDR-2-positive FB (green, small open arrow) are c-Kit-positive (red, small closed arrows) and these are partially co-localized (yellow, large open arrows) (E–G). In Cav-1−/− mouse FAK is completely absent but vWF (green, arrows) appears at CEC (D). c-Kit, also, is completely absent but DDR-2 (green, arrows) appears at FB (H). CM is cardiomyocyte and IS is interstitial space. Scale bar is 10 μm for all images.