1.
Clinical and biochemical characteristics of study subjects
| [spanname =“3to8”]Diabetic patients | |||||||
|---|---|---|---|---|---|---|---|
| Controls | At onset [DO] | [<1.5D] | [1.5–5D] | [5–10D] | [10–20D] | [+DC] | |
| n | 140 | 75 | 30 | 48 | 61 | 40 | 34 |
| Age (years, mean ± SD) | 13.7±9.3 | 9.1±3.7 | 9.7±4.3 | 12.2±3.8 | 16.1±4.3 | 20.1±4.5 | 25.9±4.3 |
| (Range) | (1–30) | (1–17) | (3–18) | (5–22) | (7–24) | (13-27) | (20-36) |
| Diabetes duration (years) | – | – | 0.88±0.06 | 3.28±0.16 | 7.44±0.175 | 14.7±0.5 | 18.96±1.1 |
| (Range) | (13-32) | ||||||
| HbA1c (%) | (4.6–6.6)* | 11.6±0.3 | 8.2±0.2 | 9.03±0.22 | 8.7±0.24 | 8.39±0.29 | 8.4±0.3 |
| Fructosamine (μM) | (180–285)* | 488.6±18.7 | 360.4±18.7 | 371.4±15.3 | 399.4±15.3 | 388.5±12.3 | 384.4±15.1 |
| Cholesterol (mM) | 4.04±0.05 | 4.8±0.11c | 4.2±0.11 | 4.6±0.11c | 4.6±0.11c | 4.8±0.14c | 4.85±0.17c |
| Triglycerides (mM) | 0.6±0.02 | 0.81±0.05b | 0.6±0.04 | 0.57±0.03 | 0.69±0.05 | 0.97±0.09c | 1.17±0.14c,d |
| Uric acid μM) | 239.5±7.1 | 154±6.2c | 190±10.7b | 184.6±9.5c | 229.6±10.3 | 204.07±14a | 221.4±22.9 |
| -Tocopherol/TL (μM/mM) | 5.18±0.09 | 4.75±0.14a | 4.63±0.13a | 4.69±0.12a | 4.9±0.1 | 5.15±0.3 | 4.4±0.27c,d |
Data are means ± SEM. *Data in parentheses are normal ranges. a P<0.05, b P<0.005 and c P<0.0001 versus control subjects. d P<0.05 versus [10–20D]. Subgroups of diabetic patients: diabetes onset [DO], disease duration <1.5 years [<1.5D], disease duration from 1–5 years [1.5–5D], disease duration from 5–10 years [5–10D], disease duration from 10–20 years [10–20D], patients with microvascular complications [+DC]. TL = Total lipids.