Table S2.
Characteristics of subjects with COPD classified by annual rates of decline in FEV1 at baseline
| Classified by annual change in FEV (mL/year)
|
P-value | ||||
|---|---|---|---|---|---|
| All patients (n=261) | Rapid decliners (n=65) | Slow decliners (n=131) | Sustainers (n=65) | ||
| Age, y | 70±8 | 69±6 | 70±8 | 68±9 | 0.11 |
| Female sex, n (%) | 15 (5) | 1 (2) | 10 (8) | 4 (6) | 0.22 |
| BMI (kg/m2) | 22±3 | 21±3* | 22±3 | 23±4 | 0.017 |
| Current smoker at entry, n (%) | 73 (28) | 13 (20) | 40 (31) | 20 (31) | 0.26 |
| Pack-years at entry | 63±30 | 67±27 | 64±33 | 55±25 | 0.05 |
| FEV (l) | 1.75±0.67 | 1.76±0.62 | 1.71±0.66 | 1.84±0.67 | 0.42 |
| FEV1 (%predicted) | 65±22 | 64±21 | 64±22 | 66±23 | 0.74 |
| DLco (mmol/min/mmHg) | 12±5 | 11±5* | 12±5* | 14±4 | 0.003 |
| Any cardiovascular disease, n (%) | 58 (22) | 17 (26) | 27 (21) | 14 (22) | 0.67 |
| Ischemic heart disease, n (%) | 18 (7) | 3 (5) | 8 (6) | 7 (10) | 0.36 |
| Diabetes, n (%) | 12 (5) | 1 (2) | 7 (5) | 4 (6) | 0.31 |
Notes: Values are means ± SD; other values are numbers (%); P-values represent one-way analysis of variance with post hoc comparisons using Tukey’s multiple comparison tests;
*
P<0.05 versus sustainers.
Abbreviations: BMI, body mass index; COPD, chronic obstructive pulmonary disease; DLco, carbon monoxide diffusing capacity; FEV1, forced expiratory volume in 1 second; SD, standard deviation.