Table S5.
Results of unadjusted and adjusted linear mixed-effects models to identify which variables at baseline were predictive of the annual change in SGRQ impact scores at 5 years
| Variable | Unadjusted models
|
Adjusted models
|
||
|---|---|---|---|---|
| Estimate (95% CI) | P-value | Estimate (95% CI) | P-value | |
| Age* | 0.83 (0.03, 0.13) | 0.001 | 0.61 (0.01, 0.11) | 0.021 |
| BMI | −0.12 (−0.24, −0.00) | 0.042 | −0.07 (−0.19, 0.06) | 0.312 |
| FVC (%predicted)‡ | −0.23 (−0.04, −0.00) | 0.026 | −0.02 (−0.03, 0.03) | 0.857 |
| FEV1 (%predicted)‡ | −0.33 (−0.05, −0.02) | <0.001 | −0.03 (−0.05, 0.00) | 0.052 |
| DLco (ml/min/mmHg) | −0.15 (−0.23, −0.07) | <0.001 | −0.04 (−0.14, 0.05) | 0.369 |
| Eosinophils (μl)§ | −0.35 (−0.00, −0.00) | 0.017 | −0.31 (−0.01, 0.00) | 0.028 |
Notes:
*
Analyzed in units of 10 years;
‡
Analyzed in units of 10%;
§
Analyzed in units of 100.
Abbreviations: BMI, body mass index; CI, confidence interval; DLco, carbon monoxide diffusing capacity; FEV1, forced expiratory volume in 1 second; FVC, forced vital capacity; SGRQ, St George’s Respiratory Questionnaire.