Table 3.

Negative predictive value for absence of potential algorithm components within 30 days before or after the index date

Sampling algorithm	Total	Absence confirmed by medical record
		Bone metastases		Nonbone metastases		Any metastases
		n	NPV (95% CI)	n	NPV (95% CI)	n	NPV (95% CI)
PSA ≤50 μg/L and no ART or bone scintigraphy	99	99	1.00 (0.96–1.00)	99	1.00 (0.96–1.00)	99	1.00 (0.96–1.00)
PSA ≤50 μg/L regardless of ART or bone scintigraphy	139a	137	0.99 (0.95–1.00)	137	0.99 (0.95–1.00)	135	0.97 (0.93–0.99)

Notes:

^aIncludes 99 patients with PSA ≤50 μg/L and no ART or bone scintigraphy and 40 patients with PSA ≤50 μg/L with ART or bone scintigraphy.

Abbreviations: ART, antiresorptive therapy; CI, confidence interval; NPV, negative predictive value; PSA, prostate-specific antigen.