. Author manuscript; available in PMC: 2015 Oct 1.

Published in final edited form as: Immunol Lett. 2014 Jun 2;161(2):231–235. doi: 10.1016/j.imlet.2014.04.004

Table 1.

Murine models of IBD.

Chemically induced	Cell transfer into immune-deficient animal	Conventional or conditional KO	Conventional or conditional Tg	KI	Spontaneous
DSS TNBS Oxalazone Acetic Acid	CD45RB into SCID or RAG^−/−, Bone marrow intotgε26 mice, CD8⁺ T cells into RAG^−/−	IL-2^−/− IL-2Rα^−/− IL-2Rβ^−/− IL-10^−/− JAK3^−/− TCRα^−/− TGFβ^−/− WASP^−/− SHIP1^−/− TLR5^−/− RUNX3^−/− Keratin 8^−/− Mdr1a^−/− Muc2^−/− A20^−/− Epi/TAK1^−/− CD4/TGFβ^−/− CD4/PDK1^−/− GPX1/2^−/− T/Blimp1^−/− Endothelial/αV^−/− Epi/C1GalT1^−/− Myeloid/STAT3^−/− Inducible STAT3^−/− DC/β8^−/− Epi/NEMO^−/− Epi/XBP1^−/− Thymus/Atg5^−/−	T/TNFSF15, T/LIGHT, Epi/IL-15, T/CD40L, B/CD40L, Liver/sol.B7.2, T/SOCS1, Inducible-STAT4, DNTGFβRII	TNF(ARE), P13Kp110d, Gp 130, Epi/N-cadherin	SAMP1/YitFc, C3H/HeJBir, Cotton-topTamarin

KO, knockout; Tg, transgenic; KI, knock-in; DSS, dextran sulfate sodium; TNBS, trinitrobenzene sulfonic acid.