Table 3.
Final Proportional Hazards Model for Lung Cancer Specific Survival
Variable | HR | 95%CI | P>X2 |
---|---|---|---|
Treatment | |||
Lobectomy (Baseline) | 1.00 | -- | -- |
Sublobar Resection | 1.50 | 1.29 – 1.75 | <.001 |
SABR | 1.44 | 1.03 – 2.02 | 0.03 |
Age | |||
66–69 (Baseline) | 1.00 | -- | -- |
70–74 | 1.29 | 1.09 – 1.52 | <.001 |
75–79 | 1.37 | 1.16 – 1.62 | <.001 |
≥80 | 1.66 | 1.40 – 1.98 | <.001 |
Sex | |||
Male (Baseline) | 1.00 | -- | -- |
Female | 0.75 | 0.67 – 0.83 | <.001 |
Educational Attainment | |||
1st Quartile (0 – 10%) | 1.00 | -- | -- |
2nd Quartile (10 – 17%) | 1.15 | 0.99 – 1.33 | 0.07 |
3rd Quartile (17 – 27%) | 1.21 | 1.04 – 1.40 | 0.01 |
4th Quartile (>27%) | 1.30 | 1.11 – 1.51 | 0.00 |
COPD | |||
No (Baseline) | 1.00 | -- | -- |
Yes | 1.25 | 1.16 – 1.34 | <.001 |
Charleson Comorbidity Score Ex. COPD | |||
0 (Baseline) | 1.00 | -- | -- |
1 | 1.03 | 0.90 – 1.17 | 0.69 |
≥2 | 1.30 | 1.13 – 1.49 | <.001 |
Oxygen Supplementation | |||
No (Baseline) | 1.00 | -- | -- |
Yes | 1.35 | 1.17 – 1.55 | <.001 |
T-Stage | |||
T1A (0.0 – 2.0 cm) (Baseline) | 1.00 | -- | -- |
T1B (2.1 – 3.0 cm) | 1.30 | 1.15 – 1.47 | <.001 |
T2A (3.1 – 5.0 cm) | 1.60 | 1.40 – 1.83 | <.001 |
Histology | |||
NSCLC, NOS (Baseline) | 1.00 | -- | -- |
Adenocarcinoma | 0.82 | 0.67 – 1.01 | 0.06 |
Squamous carcinoma | 0.95 | 0.77 – 1.17 | 0.63 |
Large cell | 0.99 | 0.72 – 1.35 | 0.94 |
Mediastinal Sampling | |||
Not Performed (Baseline) | 1.00 | -- | -- |
Performed | 0.78 | 0.78 – 0.78 | <.001 |
Year of Diagnosis | |||
2003 (Baseline) | 1.00 | -- | -- |
2004 | 0.92 | 0.79 – 1.08 | 0.31 |
2005 | 0.96 | 0.81 – 1.13 | 0.59 |
2006 | 0.90 | 0.75 – 1.08 | 0.26 |
2007 | 0.76 | 0.62 – 0.94 | 0.01 |
2008 | 0.76 | 0.59 – 0.97 | 0.03 |
2009 | 0.55 | 0.36 – 0.84 | 0.01 |
Abbreviations: HR, hazard ratio; CI, confidence interval; SABR, stereotactic ablative radiation; Ex, excluding; NSCLC, NOS, non-small cell lung cancer, not otherwise specified