Table 5. Evaluation of baseline characteristics as predictive factor of infection in patients treated with single agent PI3K-AKT-mTOR inhibitors.
| Infection indicators | Odds Ratio | P | 95% Lower CI. | 95% Upper CI. |
|---|---|---|---|---|
| Age | 1.01 | 0.524 | 0.99 | 1.02 |
| PS | 1.38 | 0.23 | 0.81 | 2.35 |
| RM Score | 0.82 | 0.127 | 0.64 | 1.06 |
| BMI | 1 | 0.991 | 0.99 | 1.01 |
| Baseline albumin | 1 | 0.878 | 0.95 | 1.05 |
| Baseline LHD | 1 | 0.057 | 1 | 1 |
| Baseline white cell counts | 1 | 0.854 | 0.94 | 1.05 |
| Baseline neutrophils count | 0.98 | 0.702 | 0.91 | 1.07 |
| Baseline lymphocytes count | 1.19 | 0.198 | 0.92 | 1.54 |
| Baseline N/L ratio | 0.98 | 0.617 | 0.9 | 1.07 |
| Number of metastatic sites | 0.88 | 0.633 | 0.52 | 1.48 |
| Number of cycles received | 1.0880 | 0.012 | 1.01 | 1.16 |
| History of Type 1 DM | 9.91e-07 | 0.985 | 0 | - |
| History of Type 2 DM | 0.64 | 0.68 | 0.07 | 5.4359 |
The only predictive factor of infection with PI3K-AKT-mTOR inhibitors is the number of cycles of treatment. Patients who were on the treatment for longer time were more likely to develop infection.