Table 1. Summary results of meta-analysis by hemostatic markers.

Hemostatic marker	Pooled SMD with 95% CI	Test for overall effect (P value)	Heterogeneity
			Q-test (P value)	I2 (%)
Platelet activation
Platelet count	-0.29 (-0.59–0.02)	0.066	<0.001	90.2
MPV	0.92 (0.12–1.73)	0.025	<0.001	97.3
PF-4	1.72 (0.96–2.49)	<0.001	<0.001	95.5
BTG	1.61 (1.03–2.19)	<0.001	<0.001	96.0
P-selectin	0.50 (0.23–0.77)	<0.001	<0.001	90.0
Coagulation activation
D-dimer	1.82 (1.38–2.26)	<0.001	<0.001	96.6
Fibrinogen	0.72 (0.55–0.89)	<0.001	<0.001	94.0
TAT	0.42 (0.13–0.72)	0.005	0.298	18.3
F1+2	1.00 (0.00–1.99)	0.049	<0.001	97.7
AT- III	1.38 (0.16–2.60)	0.027	<0.001	95.6
Fibrinolytic function
tPA	0.86 (0.04, 1.67)	0.041	<0.001	96.7
PAI-1	0.87 (0.28–1.47)	0.004	<0.001	96.3
Endothelial function
vWf	0.79 (0.60–0.99)	<0.001	<0.001	90.1
sTM	0.60 (-0.13–1.33)	0.107	<0.001	91.6

AF, atrial fibrillation; MPV, mean platelet volume; PF-4, platelet factor 4; BTG, β-thromboglobulin; P-sel, P-selectin; Fib, fibrinogen; TAT, thrombin—antithrombin; F1+2, prothombin fragments 1+2; AT- III, Antithrombin III; tPA, tissue plasminogen activator; PAI-1, plasminogen activator inhibitor-1; vWf, vonWillebrand factor; sTM, soluble thrombomodulin; SMD, standardized mean difference; CI, confidence interval.