Table 2. Admission Day Model Performance for patients with Acetaminophen-induced Acute Liver Failure.

Admission Model	Variables in Model	Dataset Used (Sample size)	Accuracy (95% CI)	Specificity (95% CI)	Sensitivity (95% CI)	AUROC (95% CI)
KCC	pH, INR, creatinine, coma grade (low/high)	All Day 1 with non-missing values for all variables (N = 679)	0.692 (0.656–0.727)	0.895 (0.864–0.922)	0.272 (0.214–0.335)	0.582 (0.551–0.613)
KCC	pH, INR, creatinine, coma grade (low/high)	Day 1 Training Set (N = 249)	0.578 (0.514–0.640)	0.759 (0.624–0.865)	0.528 (0.456–0.600)	0.559 (0.528–0.590)
KCC	pH, INR, creatinine, coma grade (low/high)	Day 1 Test Set (N = 424)	0.804 (0.763–0.841)	0.870 (0.831–0.902)	0.292 (0.170–0.441)	0.585 (0.554–0.616)
KCC-CART	INR, creatinine, coma grade (low/high), pH	Day 1 Training Set (N = 288)	0.722 (0.667–0.773)	0.715 (0.634–0.787)	0.729 (0.649–0.800)	0.740 (0.712–0.767)
KCC-CART	INR, creatinine, coma grade (low/high), pH	Day 1 Test Set (N = 515)	0.658 (0.615–0.699)	0.652 (0.605–0.696)	0.670 (0.580–0.801)	0.704 (0.675–0.732)
NEW-CART	MELD, MV, lactate	Day 1 Training Set (N = 288)	0.750 (0.696–0.800)	0.771 (0.693–0.837)	0.729 (0.649–0.800)	0.791 (0.764–0.816)
NEW-CART	MELD, MV, lactate	Day 1 Test Set (N = 515)	0.718 (0.677–0.757)	0.710 (0.666–0.752)	0.767 (0.654–0.858)	0.755 (0.727–0.781)

Abbreviations

AUROC: Area under the receiver operator curve

CART: Classification and Regression Tree Analysis

CI: Confidence interval

Coma grade as defined by West Haven Criteria[21]: Low grade ~ Grade I or II, High grade ~ Grade III or IV

KCC: King’s College Criteria

KCC-CART: Classification and Regression Tree analysis using traditional King’s College Criteria Variables

INR: Internationalized Ratio; MELD: Model for End-Stage Liver Disease, MV: mechanical ventilation.

N: Number of patients in sample dataset with outcomes; 95% CI: 95% confidence intervals

NEW-CART: Classification and Regression Tree analysis using new Variables