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. Author manuscript; available in PMC: 2016 Apr 1.
Published in final edited form as: Adv Drug Deliv Rev. 2014 Oct 17;84:68–84. doi: 10.1016/j.addr.2014.10.010

Fig. 3.

Fig. 3

Controlled release of growth factors via mineral coated based delivery systems. A) Schematic of mineral coating formation process using mSBF. B) Mineral coating stability was affected by the extent of carbonate substitution in mineral coating during coating formation. C) Formation of mineral coating on β-TCP surface helped slow down the dissolution of the materials. D) Schematic of release and binding mechanism of growth factors to mineral coating. With higher carbonate concentration, the amount of growth factor released is greater over time. E) The release kinetics of VEGF mimic was controlled by the dissolution rate of mineral coating. F) VEGF bound on mineral coating fully preserved its bioactivity [138,140]. Reproduced with permission.