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. Author manuscript; available in PMC: 2016 Apr 1.
Published in final edited form as: Adv Drug Deliv Rev. 2014 Oct 17;84:68–84. doi: 10.1016/j.addr.2014.10.010

Fig. 4.

Fig. 4

Multiple GF release via multilayer mineral coating with tuned stability: A) Incorporation of fluoride into mineral coating decelerated the dissolution of mineral coating. B) Dual release of BMP-2/VEGF was achieved by using multilayered microparicles. BMP-2 was released in a sustained manner while VEGF was liberated from mineral coating relatively faster. C) Control over BMP-2 release by changing the coating thickness on the microparticles [142]. Reproduced with permission.