Fig 1. Weanling mice exhibit spatial learning in the Morris water maze (MWM).

Spatial learning was assessed as a function of training day with respect to the following parameters: (A) escape latency, (B) percentage of time spent in the target quadrant, and (C) percentage of total path length spent in the target quadrant. Data are presented as the mean ± SEM (n = 16 animals). Since sex differences were not identified for any of the behavioral parameters shown in this Fig., data from males and females were combined to calculate mean values. Significantly different from training d 1 (A) or d 2 (B and C) at ^a p < 0.05, ^b p < 0.01, ^c p < 0.001 as determined using repeated measures ANOVA with LSD post hoc test. Effect sizes: partial η² for latency = 0.31, partial η² for % time = 0.21; partial η² for % path length = 0.17. Power: 99% for latency, 94% for % time, 84% for % path length. Note that escape latency was the only data collected on the first day of training because of a computer malfunction in collecting data on the first training day.