Skip to main content
. Author manuscript; available in PMC: 2015 Apr 17.
Published in final edited form as: Cell Rep. 2015 Mar 26;11(1):111–124. doi: 10.1016/j.celrep.2015.03.002

Figure 5. Rab2A/p-Erk Signaling Promotes the Nuclear Translocation of Activeβ-Catenin.

Figure 5

(A and B) Rab2A promoted the nuclear translocation of unphosphorylated β-catenin (active form). HMLE cells were serum starved and then stimulated by EGF for the indicated time points.

(C–E) Pin1 also promoted the nuclear translocation of unphosphorylated β-catenin and Rab2A overexpression in Pin1 KD cells rescued Erk1/2 activation and β-catenin translocation from the cell membrane to the nucleus.

(F and G) Rab2A KD in Pin1-overexpressing or vector control cells inhibited p-Erk1/2 activation and β-catenin nuclear translocation. Scale bars represent 10 μm.

(H) Rab2A promoted the nuclear accumulation of p-Erk1/2 and unphosphorylated β-catenin. Nuclear and total proteins were extracted after EGF stimulation following serum starvation.