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. Author manuscript; available in PMC: 2015 Apr 17.
Published in final edited form as: Cell Rep. 2015 Mar 26;11(1):111–124. doi: 10.1016/j.celrep.2015.03.002

Figure 7. Rab2A Expression Correlates with Pin1 and ALDH1 Expression and with Poor Clinical Outcome in Breast Cancer Patients.

Figure 7

(A–C) Rab2A expression correlated with Pin1 and ALDH1 expression in the tissue array of normal and cancerous breast tissue.

(D) High Rab2A expression correlated with poor overall survival in the tissue array dataset of breast cancer patients.

(E) Rab2A was a strong and independent biomarker to predict breast cancer specific survival in the Curtis breast cancer dataset by Cox regression analyses.

(F) Boxplots of Rab2A expression stratified by the PAM50 classifier in the Curtis breast cancer dataset.

(G) Boxplots of Rab2A expression stratified by the IntClust subtypes in the Curtis breast cancer dataset.

(H) Univariate Cox regression analysis showed that HER2-negative, non-triple-negative, or PAM50-normal subtypes of breast cancer patients with higher Rab2A mRNA levels had a higher risk of breast cancer mortality.

(I) A schematic model for how the Pin1/Rab2A/Erk signal pathway regulates tumor initiation via CSC regulators, contributing to high mortality in breast cancer. See also Figure S7.