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. 2015 Apr 17;10(4):e0124661. doi: 10.1371/journal.pone.0124661

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© 2015 Siegemund et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Fig 3 — (A) Thymocyte populations were identified by the gating strategy in the upper panel [13,31–33]. Lower panel, EYFP expression in the indicated thymocyte populations from hCD2-iCre ^+/- R26-stop-EYFP ^+/- (open histograms) or R26-stop-EYFP ^+/- mice (shaded histograms). Numbers denote % EYFP⁺ cells within the indicated population of hCD2-iCre ^+/- R26-stop-EYFP ^+/- mice. Representative of three independent experiments (n = 3). (B) Upper panel, subsets of developing B cells in the BM were distinguished as in [19]. Lower panel, EYFP expression in the indicated BM B cell populations from hCD2-iCre ^+/- R26-stop-EYFP ^+/- (open histograms) or R26-stop-EYFP ^+/- mice (shaded histograms). Numbers denote % EYFP⁺ cells within the indicated population of hCD2-iCre ^+/- R26-stop-EYFP ^+/- mice. Representative of three independent experiments (n = 3). (C) Upper panels, NK cell progenitors (NKP), immature (iNK) and mature (mNK) NK cells were identified using the indicated gating strategy [18,29]. Lower panels, EYFP expression in the indicated BM and splenic NK cell populations from (top, n = 3 per genotype) hCD2-iCre ^+/- R26-stop-EYFP ^+/- (open histograms) or R26-stop-EYFP ^+/- mice (shaded histograms), or (bottom, n = 2 per genotype) from Vav-iCre ^+/- R26-stop-EYFP ^+/- (open histograms) or R26-stop-EYFP ^+/- mice (shaded histograms). Numbers indicate % EYFP⁺ cells in the respective Cre ^+/- mice. Representative of three independent experiments with hCD2-iCre transgenic mice, and of two independent experiments with Vav-iCre transgenic mice.