Table 4.
Cause of death and selected adverse events occurring with IC and CRT
| APF-C and CRT (n = 30) | TPF-C and CRT (n = 38) | P value2 | |
|---|---|---|---|
| Number of patients (%) | |||
| Cause of death | |||
| Disease progression | 1 (3) | 15 (39) | – |
| Second malignancy | 0 (0) | 1 (3) | – |
| Treatment-related | 1 (3) | 2 (5) | – |
| Noncancer1 | 2 (6) | 2 (5) | – |
| Total | 4 (13) | 20 (53) | – |
| Adverse event | Grade 3 or 4 | All grades | Grade 3 or 4 | All grades | |
|---|---|---|---|---|---|
| Neuropathy | 1 (3) | 17 (57) | 1 (3) | 4 (11) | 0.00014 |
| Hypersensitivity | 1 (3) | 4 (13) | 2 (5) | 11 (29) | 0.15 |
| Rash | 6 (20) | 28 (93) | 5 (13) | 29 (76) | 0.096 |
| Mucositis | 9 (30) | 25 (83) | 13 (34) | 26 (68) | 0.26 |
| Creatinine elevation | 2 (7) | 18 (60) | 1 (3) | 7 (18) | 0.00085 |
1
Includes bowel obstruction (n = 1) and unknown (n = 2).
2
P value is for comparison of all grades of toxicities, P-values from Fisher's Exact test.