Table 1.
Functional pathways of upregulated (>twofold) or downregulated (<0.5-fold) genes in HCT116 and HT29 cells cultured in 3DC compared with 2DC
| Term | Count | P-value |
|---|---|---|
| KEGG pathway database | ||
| Cell cycle | 19 | 1.2 E−8 |
| Oocyte meiosis | 14 | 1.4 E−5 |
| Glycolysis/gluconeogenesis | 8 | 1.6 E−3 |
| Progesterone-mediated oocyte maturation | 9 | 3.2 E−3 |
| Systemic lupus erythematous | 9 | 7.5 E−2 |
| Antigen processing and presentation | 4 | 9.1 E−2 |
| BIOCARTA | ||
| How progesterone initiates the oocyte maturation | 4 | 9.9 E−1 |
| Glycolysis pathway | 3 | 9.8 E−1 |
| Role of Ran in mitotic spindle regulation | 9 | 9.5 E−1 |
| Stathmin and breast cancer resistance to antimicrotubule agents | 14 | 9.3 E−1 |
3DC, three-dimensional culture; 2DC, two-dimensional culture; KEGG, Kyoto Encyclopedia of Genes and Genomes.