Table 3.

Group differences in modular connectivity

	M patients (SD)	M controls (SD)	B [95% CI]	t	P-value
Functional connectome
Between-module
aDMN+	0.440 (0.115)	0.492 (0.005)	0.728 [−0.274 to 1.729]	1451	0.152
pDMN+	0.470 (0.116)	0.451 (0.014)	−0.768 [−1.797 to 0.262]	−1490	0.141
SMM	0.484 (0.116)	0.457 (0.006)	−0.497 [−1.550 to 0.555]	−0.944	0.349
POM	0.432 (0.118)	0.475 (0.005)	0.601 [−0.407 to 1.610]	1190	0.238
Within-module
aDMN+	−0.066 (0.178)	−0.0001 (0.031)	0.803 [0.163 to 1.443]	2507	0.015
pDMN+	−0.132 (0.379)	0.003 (0.057)	0.363 [0.055 to 0.670]	2355	0.022
SMM	−0.013 (0.237)	−0.003 (0.043)	−0.241 [−0.748 to 0.267]	−0.948	0.347
POM	0.139 (0.150)	0.003 (0.034)	−1.290 [−1.926 to −0.653]	−4048	<0.001*
Anatomical connectome
Between-module
Global average	0.134 (0.070)	0.219 (0.030)	2.673 [1.358 to 3.988]	4060	<0.001*
Functional aDMN+	0.127 (0.066)	0.205 (0.042)	2.470 [1.053 to 3.886]	3481	0.001*
Functional pDMN+	0.136 (0.083)	0.254 (0.047)	2.452 [1.483 to 3.421]	5053	<0.001*
Within-module
Functional aDMN+	0.005 (0.055)	0.018 (0.063)	0.743 [−0.942 to 2.427]	0.880	0.382
Functional pDMN+	0.136 (0.083)	0.254 (0.047)	0.901 [0.316 to 1.486]	3077	0.003*

All regression models corrected for motion, age, sex, and hippocampal volumes. aDMN+/pDMN+, anterior/posterior default mode network; SMM, sensorimotor network module; POM, parieto-occipital module.

^*P < 0.05 (after FDR correction).