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. 2015 Mar 12;2(4):401–416. doi: 10.1002/acn3.183

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© 2015 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Methyl supplementation decreases interictal spiking. (a) Diagram of experimental setup. (b) Representative trace of interictal spikes observed in epileptic rats 3 weeks post-KA administration (* represents what was counted as a spike). (c) Methyl supplementation significantly reduced interictal spike number in the first 24 h postinjection. Interictal spiking rate showed a trend toward returning back to baseline at 24–48 h post-Met supplementation (F_2,6 = 4.06, P < 0.05, n = 7, one-way analysis of variance [ANOVA] with post hoc test, *significance relative to pre-Met). (d) Methyl supplementation did not have a significant effect on number of seizures per day (F_2,18 = 0.82, P > 0.05, n = 7, one-way ANOVA with post hoc test). (e) Methyl supplementation did no significantly affect duration of seizures (F_2,23 = 0.91, P > 0.05, n = 3–16, one-way ANOVA with post hoc test, ns = not significant). Error bars are SEM.