Table 2.
Odds ratios (ORs) and 95% Confidence Intervals (CIs) for the Association Between Single Nucleotide Polymorphisms (SNPs) on AURKA and All Incident Cases of Breast Cancer by Race
| SNP | Caucasian cases and controls
|
African American cases and controls
|
||
|---|---|---|---|---|
| ORa (95% CI) | Padj b | ORa (95% CI) | Padj b | |
| rs1047972 | ||||
| AG + AA | 1.05 (0.87, 1.27) | 0.99 | 0.97 (0.76, 1.24) | 0.92 |
| GG | Referent | Referent | ||
| rs34987347c | ||||
| TC + TT | 1.04 (0.34, 1.27) | 0.99 | ||
| CC | Referent | Referent | ||
| rs1468056 | ||||
| CG + CC | 1.09 (0.91, 1.30) | 0.99 | 1.05 (0.75, 1.47) | 0.92 |
| GG | Referent | Referent | ||
| rs16979826d | ||||
| CT + CC | 0.96 (0.73, 1.27) | 0.92 | ||
| TT | Referent | |||
| rs16979829 | ||||
| GT + GG | 1.10 (0.77, 1.58) | 0.99 | 0.97 (0.77, 1.23) | 0.92 |
| TT | Referent | Referent | ||
| rs16979865 | ||||
| CA + CC | 1.07 (0.84, 1.38) | 0.99 | 0.85 (0.64, 1.13) | 0.92 |
| AA | Referent | Referent | ||
| rs2180691 | ||||
| AG + AA | 0.99 (0.84, 1.18) | 0.99 | 0.90 (0.56, 1.45) | 0.92 |
| GG | Referent | Referent | ||
| rs2273535 | ||||
| TA + TT | 1.00 (0.84, 1.20) | 0.99 | 1.07 (0.84, 1.36) | 0.92 |
| AA | Referent | Referent | ||
| rs2298016 | ||||
| CG + CC | 1.01 (0.85, 1.21) | 0.99 | 0.97 (0.78, 1.21) | 0.92 |
| GG | Referent | Referent | ||
| rs6014711 | ||||
| AG + AA | 1.04 (0.86, 1.25) | 0.99 | 0.97 (0.76, 1.23) | 0.92 |
| GG | Referent | Referent | ||
| rs6024840 | ||||
| GA + GG | 1.02 (0.86, 1.25) | 0.99 | 0.80 (0.62, 1.04) | 0.70 |
| AA | Referent | Referent | ||
| rs6092309 | ||||
| AG + AA | 2.13 (0.47, 9.65) | 0.99 | 0.69 (0.53, 0.90) | 0.14 |
| GG | Referent | Referent | ||
| rs6099122 | ||||
| GT + GG | 1.20 (0.79, 1.81) | 0.99 | 0.86 (0.69, 1.07) | 0.92 |
| TT | Referent | Referent | ||
| rs6099126 | ||||
| TC + TT | 1.10 (0.74, 1.63) | 0.99 | 0.89 (0.71, 1.12) | 0.92 |
| CC | Referent | Referent | ||
| rs6099128 | ||||
| GT + GG | 0.85 (0.98, 1.06) | 0.99 | 0.81 (0.64, 1.02) | 0.70 |
| TT | Referent | Referent | ||
| rs1468055 | ||||
| AC + AA | 1.06 (0.88, 1.26) | 0.99 | 0.95 (0.63, 1.41) | 0.92 |
| CC | Referent | Referent | ||
| rs6024836 | ||||
| AG + AA | 1.02 (0.86, 1.22) | 0.99 | 0.95 (0.67, 1.35) | 0.92 |
| GG | Referent | Referent | ||
| rs2064863 | ||||
| AC + AA | 1.00 (0.83, 1.20) | 0.99 | 0.91 (0.50, 1.64) | 0.92 |
| CC | Referent | Referent | ||
| rs6099119 | ||||
| GA + GG | 2.08 (0.21, 20.73) | 0.99 | 1.11 (0.77, 1.62) | 0.92 |
| AA | Referent | Referent | ||
| rs911162 | ||||
| AG + AA | 0.82 (0.41, 1.67) | 0.99 | 1.23 (0.82, 1.84) | 0.92 |
| GG | Referent | Referent | ||
a
Case-control odds ratio and 95% confidence interval adjusted for age, African ancestry and offset term.
b
False discovery rate (FDR) adjusted P-values.
c
Too few heterozygotes and homozygotes for the minor allele in Caucasian.
d
Tag SNP only in African Americans.